The Life and Death of Proteins

Course Description

Summary

This is an advanced literature-based course aimed at understanding the events that follow the transcription of a DNA sequence into a messenger RNA and the subsequent translation of that message into an amino acid sequence, or protein. The primary emphasis will be on experimental design and interpretation in the context of critical reading, discussion, and writing informed summaries of the primary literature. We will focus on selected “case studies” and read fundamental papers that have led to a greater understanding of each particular area. By following the historical development of specific topics, we will evaluate how different experimental cell biological, genetic and biochemical approaches contribute to our understanding of a biological problem. Topics will include: How do proteins fold? What are molecular chaperones and how do they contribute to protein folding? How are proteins targeted to their correct cellular location? How are proteins recognized and targeted for degradation?